FLUOROSIS RESEARCH AND REFERRAL LABORATORY

Overview

The Fluorosis Research and Referral Laboratory (FRRL) provide location specific and meaningful strategies to mitigate the fluorosis and it’s linked disorders. The center was identified as a Center of Excellence by the Academy vide reference No. SDUAHER/KLR/ADMN/330/2020-21 dated 14.10.2020.

Vision

To involve in diverse aspects of fluoride research in health and disease in Humans and animal models, to extend its services to Horticulture, Agriculture, Animal Husbandry and community at large.

Mission

  • This laboratory was established for the purpose of estimating the fluoride levels in biological fluids as Kolar District is endemic for fluorosis.
  • To make this Laboratory a Referral Lab for fluorosis
  • To create a center of excellence with respect to impact of fluoride in health and disease.

Objectives

  • To estimate the fluoride content in biological fluids as a means of fulfilling a social obligation towards a public health problem.
  • This would fulfill both societal as well as meet community health services. It can be used for patient care as well as research purposes.

Programs

Functional MoU

MoU titled “Fluoride related research and IPR related activities” pertaining to Fluorosis research was signed between Sri Devaraj Urs Academy of Higher Education and Research, Kolar and Acharya Institutes, Bangalore on 12- 07- 2017.

Guest Lecture

“Fluorosis” by Dr. Bapuji M and Dr. Krishna Rao on 12 – 04- 2017.

State Level CME

“ Minerals in health and disease with special emphasis on Fluoride” on 12 – 05 – 2017.

National Webinar

“Fluorosis and its Global Perspective” was conducted on 06.03.2021 to create awareness on fluorosis and disseminate the information.

New Knowledge Generated: Academic researchers and advanced practitioners deliberated on fluoride containing dental products like fluoride gel, fluoride varnish, mouth rinses and fluoride containing tooth pastes also contain high amount of fluoride but adolescents and professional’s knowledge on this product and their fluoride concentration is very low. Many natural adsorbents from various trees and animal sources have been tried as defluoridation agents.

Seeds of the drumstick, tamarind seeds, tea ash, and egg shell powder are few among them. This new knowledge generated can help in establishing effective ways to mitigate fluorosis.

Research & Publications

Instrumentation at Fluorosis Referral & Research Laboratory for fluoride analysis

Publications

  1.  GS Meghana, R Kalyani, ME Sumathi, SR Sheela. Significance of Copper, Zinc, Selenium and Fluoride in Squamous Cell Carcinoma of Cervix- A Pilot Study. Journal of Clinical and Diagnostic Research. 2019;13(5): EC17-EC20.
    2.    Sai Deepika. R, Shashidhar. Kurpad Nagaraj, Pattrapalli Nadipanna Sreeramulu. Mysterious Mineral: Fluoride. J Evolution Med. Dent sci. 2019; 8(48); 6317- 6323.
    3.    Mohan Krishna, Munilakshmi. U, Sai Deepika. R, Shashidhar K.N and Bhuneswar Yadav. Estimation of Serum Fluoride and Renal Parameters in Diabetic Nephropathy- A facility Based Observational Case Control Study. Biomedical & Pharmacology Journal. 2020; 13(2): 571-576

Research Projects (Ongoing)

Sl. No.

Topic

Investigators

Remarks

Fluoride: A missing link between Diabetes Type 2 and Micro vascular complications.

A Tertiary care Rural Hospital Case Control Study

Principal Investigator

Dr. Shashidhar K.N

Co-Investigators

Dr. Deena Mendez

Dr. Munilakshmi .U

Dr. Raveesha

Dr. Sangeetha. T

SDUAHER Funded

Role of Fluoride and oxidative stress parameters in senile cataract: A tertiary care hospital study

PhD Scholar

Dr. Sangeetha. T

Co- Supervisor

Dr. Shashidhar KN

Dr. Suresh TN

Ph.D Thesis Work

Estimation of Fluoride and Sirituin 1 in Patients with diabetic Nephropathy in Kolar District of Karnataka , India

Principal Investigator

Mrs. Sai Deepika

Supervisor

Dr. K.N. Shashidhar

Co-supervisors

Dr. C. Muninarayana. C

Dr. A Raveesha

Ph.D Thesis Work

Histomorphological change and glutamate levels in Fluoride and Arsenic induced injury to Hippocampus and cerebral cortex in Wistar rats and ameliorating effects of Ginkgobiloba

Principal Investigator

Mr. Suresh.T

Supervisor

Dr. C.V. Raghuveer

Co-supervisor

Dr. Venkateshu K.V

Dr. Kiranmayee P

Ph.D Thesis Work

Correlation of serum and urine fluoride with anemia and maternal  perinatal outcome in pregnancy

Post Graduate MS OBG

Dr. Sneha Singh

Supervisor

Dr. Munikrishna

Co- Guide

Dr. Shashidhar.K.N

PG Dissertation

Association of plasma fluoride levels with occurrence of pre-diabetes in three endemic villages of Kolar district

Principal Investigator

Dr. Sumathi.M.E

Co-investigator

Dr. V. Lakshmaiah

Dr. Shashidhar.K.N

Dr. Hariprasad.S

Dr. Ravishankar.S

SDUAHER Funded

Effect of moringa olifera leaves on hematological profile and histomorphology of brain, liver, spleen and kidneys of fluorosis affected rats

Principal Investigator

Mrs. Pravallika P

Supervisor:

Dr. Vinutha Shankar

Co-supervisors

Dr. Shashidhar.K.N

Dr. Hemalatha

SDUAHER Funded

Serum biomarkers, serum fluoride levels estimation with histopathological changes in placenta of preeclamptic women

Principal Investigator

Mrs. Krishnaveni

Supervisor

Dr. C.V. Raghuveer

Co-supervisors

Dr. Sheela S.R.

Dr. Venkateshu K.V

Dr. Prabhavathi. K

Ph.D Thesis Work

Knowledge and awareness about fluorosis in rural population of Kolar district

Principal Investigator

Dr. Sumathi M E

Co-Investigator as Junior Research Fellow

Ms Sangeetha P

Project Completed

Influence of Fluorosis on Genetic predisposition due to single nucleotide Polymorphism of LOX1 gene in pseudoexfoliation syndrome

Principal Investigator

Dr. Chaitra MC

Co- Investigator

Dr. Rashmi G

Dr. Sumathi M E

Dr. Sharath B

Dr. SM Azeem Mohiyuddin

Mrs. Apoorva HM

SDUAHER Funded

Impact of increased fluoride intake on function of Thyroid hormones in Kolar district- An area endemic for fluorosis.

Principal Investigator

Ms. Nagina. R

Guide:

Dr. Deena C Mendez

MSc. MLT Clinical Biochemistry Project

Association of Vitamin D binding protein in Diabetic retinopathy

Principal Investigator

Mr. Bhuneshwar Yadav

Co- Investigator

Dr. Shashidhar KN

Ph.D Thesis Work

Faculty

Dr. Shashidhar. K.N

Professor & Vice Principal

Dr. Deena C Mendez

Assistant Professor

Dr. Munilakshmi. U

Assistant Professor